Expression of resistance to tetracyclines in strains of methicillin-resistant Staphylococcus aureus.

@article{Trzcinski2000ExpressionOR,
  title={Expression of resistance to tetracyclines in strains of methicillin-resistant Staphylococcus aureus.},
  author={K Trzcinski and Ben S. Cooper and Waleria Hryniewicz and Christopher G. Dowson},
  journal={The Journal of antimicrobial chemotherapy},
  year={2000},
  volume={45 6},
  pages={763-70}
}
A diverse collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates resistant to tetracycline was screened by PCR for the presence of the resistance determinants tetK, tetL, tetM or tetO. Twenty-four of 66 isolates had tetM alone, 21 had tetK alone and 21 had both tetK and tetM (tetKM). All isolates were tetL- and tetO-negative. MICs of tetracycline, doxycycline and minocycline were evaluated for all isolates with or without preincubation in the presence of subinhibitory… CONTINUE READING

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