Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse.

@article{Fuchs2002ExpressionOR,
  title={Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse.},
  author={S{\'e}bastien Fuchs and St{\'e}phane Germain and Josette Philippe and Pierre Corvol and Florence Pinet},
  journal={The American journal of pathology},
  year={2002},
  volume={161 2},
  pages={717-25}
}
Renin plays a central role in controlling blood pressure as it catalyzes the first step in the production of angiotensin II. The aim of this study was to isolate fragments of the human renin (hREN) promoter able to direct tissue-specific and regulated expression of a LacZ reporter gene mimicking endogenous renin. We screened several hREN promoter/LacZ constructs for transgene expression in transient embryos at E15 when renin expression begins. We found that a 12-kb hREN promoter conferred high… CONTINUE READING