Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease.

@article{Ritthaler1995ExpressionOR,
  title={Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease.},
  author={U Ritthaler and Yuping Deng and Yu Zhang and Johannes Greten and Margaret Abel and Bernd Sido and J. R. Allenberg and G. V. E. Otto and H V Roth and Angelika Bierhaus},
  journal={The American journal of pathology},
  year={1995},
  volume={146 3},
  pages={688-94}
}
The cellular interactions of advanced glycation end products (AGEs), which have been hypothesized to contribute to the development of vascular lesions, occur, at least in part, through their binding to a novel integral membrane protein, the receptor for AGEs (RAGE). Studies of human vascular segments show that endothelial RAGE expression at the antigen and mRNA level was variable and usually at low levels in samples from healthy individuals. In contrast, patients with a range of peripheral… CONTINUE READING

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