Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis.

@article{Kerr2004ExpressionOR,
  title={Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis.},
  author={Peter J. Kerr and H. Douglas Perkins and Brett Inglis and Ron Stagg and Euan McLaughlin and S V Collins and Barbara H van Leeuwen},
  journal={Virology},
  year={2004},
  volume={324 1},
  pages={
          117-28
        }
}
Rabbit IL-4 was expressed in the virulent standard laboratory strain (SLS) and the attenuated Uriarra (Ur) strain of myxoma virus with the aim of creating a Th2 cytokine environment and inhibiting the development of an antiviral cell-mediated response to myxomatosis in infected rabbits. This allowed testing of a model for genetic resistance to myxomatosis in wild rabbits that have undergone 50 years of natural selection for resistance to myxomatosis. Expression of IL-4 significantly enhanced… CONTINUE READING

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