Expression of rRNA genes and nucleolus formation at ectopic chromosomal sites in the yeast Saccharomyces cerevisiae.

@article{Oakes2006ExpressionOR,
  title={Expression of rRNA genes and nucleolus formation at ectopic chromosomal sites in the yeast Saccharomyces cerevisiae.},
  author={Melanie L. Oakes and Katsuki Johzuka and Loan Vu and Kristilyn Eliason and Masayasu Nomura},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 16},
  pages={6223-38}
}
We constructed yeast strains in which rRNA gene repeats are integrated at ectopic sites in the presence or absence of the native nucleolus. At all three ectopic sites analyzed, near centromere CEN5, near the telomere of chromosome VI-R, and in middle of chromosome V-R (mid-V-R), a functional nucleolus was formed, and no difference in the expression of rRNA genes was observed. When two ribosomal DNA (rDNA) arrays are present, one native and the other ectopic, there is codominance in polymerase I… CONTINUE READING

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