Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target

@inproceedings{Hur2013ExpressionOP,
  title={Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target},
  author={Hoon Hur and Yi Xuan and Young Bae Kim and Gwang Lee and Wooyoung Shim and Jisoo Yun and In-hye Ham and Sang-Uk Han},
  booktitle={International journal of oncology},
  year={2013}
}
In contrast to mitochondria in healthy cells, which utilize oxidative phosphorylation, malignant cells undergo elevated glycolysis for energy production using glucose. The objectives of this study were to evaluate whether the expression of various molecules, including pyruvate dehydrogenase kinase-1 (PDK-1), is involved in the altered glucose metabolism associated with gastric cancer prognosis and to assess the role of a therapeutic… CONTINUE READING

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