Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.

@article{Greig2003ExpressionOP,
  title={Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.},
  author={Aina V. H. Greig and Claire Linge and Vourneen C Healy and Philip B Lim and Elizabeth A. Clayton and Malcolm H. A. Rustin and D. Angus Mcgrouther and Geoffrey Burnstock},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 2},
  pages={
          315-27
        }
}
We investigated the use of purinergic receptors as a new treatment modality for nonmelanoma skin cancers. Purinergic receptors, which bind adenosine 5'-tri-phosphate, are expressed on human cutaneous keratinocytes. Previous work in rat and human epidermis suggested functional roles for purinergic receptors in the regulation of proliferation, differentiation, and apoptosis. Immunohistochemical analysis of frozen sections in human basal cell carcinomas and squamous cell carcinomas for P2X5, P2X7… CONTINUE READING

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