Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

@article{Bowman1997ExpressionOP,
  title={Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.},
  author={Jason C. Bowman and Susan F. Steinberg and T Jiang and David L. Geenen and Glenn I. Fishman and Peter M. Buttrick},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 9},
  pages={2189-95}
}
Protein kinase C (PKC) activation in the heart has been linked to a hypertrophic phenotype and to processes that influence contractile function. To establish whether PKC activation is sufficient to induce an abnormal phenotype, PKCbeta was conditionally expressed in cardiomyocytes of transgenic mice. Transgene expression in adults caused mild and progressive ventricular hypertrophy associated with impaired diastolic relaxation, whereas expression in newborns caused sudden death associated with… CONTINUE READING
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