Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers.

@article{Jahan2007ExpressionOP,
  title={Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers.},
  author={Israt Jahan and Jiro Fujimoto and Syed Mahfuzul Alam and Eriko Sato and Hideki Sakaguchi and Teruhiko Tamaya},
  journal={Oncology reports},
  year={2007},
  volume={17 2},
  pages={345-50}
}
Protease activated receptor-2 (PAR-2) is the second member of a novel family of G-protein coupled seven-transmembrane domain receptors. PAR-2 has been reported to be expressed in various tumors and play a vital role in the regulation of cancer cell growth. The purpose of this study was to clarify the roles of PAR-2 in the angiogenic pathway in uterine endometrial cancers. PAR-2 expression was analyzed in 61 uterine endometrial cancer and 15 normal endometrium tissue specimens. PAR-2 histoscores… CONTINUE READING