Expression of prostate specific membrane antigen in androgen-independent prostate cancer cell line PC-3.

@article{Laidler2005ExpressionOP,
  title={Expression of prostate specific membrane antigen in androgen-independent prostate cancer cell line PC-3.},
  author={Piotr M. Laidler and Joanna D. Dulińska and Małgorzata Lekka and Janusz Lekki},
  journal={Archives of biochemistry and biophysics},
  year={2005},
  volume={435 1},
  pages={1-14}
}
During the progression of prostate cancer from androgen-dependence or sensitivity to androgen-independence, the overall expression of prostate specific membrane antigen (PSMA) increases with its appearance in plasma membrane. However, surprisingly some androgen-independent metastatic prostate cancer cell lines do not express this protein. Estradiol (E2) and basic fibroblast growth factor (bFGF) due to their recognized and strong involvement in prostate growth, development, and pathology were… CONTINUE READING

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