Expression of programmed death 1 ligands by murine T cells and APC.

  title={Expression of programmed death 1 ligands by murine T cells and APC.},
  author={Tomohide Yamazaki and Hisaya Akiba and Hideyuki Iwai and Hironori Matsuda and Mami Aoki and Yuka Tanno and Tahiro Shin and Haruo Tsuchiya and Drew Mark Pardoll and Ko Okumura and Miyuki Azuma and H. Yagita},
  journal={Journal of immunology},
  volume={169 10},
Programmed death 1 (PD-1) is a new member of the CD28/CTLA-4 family, which has been implicated in the maintenance of peripheral tolerance. Two ligands for PD-1, namely, B7-H1 (PD-L1) and B7-DC (PD-L2), have recently been identified as new members of the B7 family but their expression at the protein level remains largely unknown. To characterize the expression of B7-H1 and B7-DC, we newly generated an anti-mouse B7-H1 mAb (MIH6) and an anti-mouse B7-DC mAb (TY25). MIH6 and TY25… CONTINUE READING
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