Expression of processed core protein of hepatitis C virus in mammalian cells.

@article{Harada1991ExpressionOP,
  title={Expression of processed core protein of hepatitis C virus in mammalian cells.},
  author={Shinji Harada and Yuki Watanabe and Kaoru Takeuchi and Takeshi Suzuki and Taira Katayama and Yutaka Takebe and Izumu Saito and Tatsuo Miyamura},
  journal={Journal of virology},
  year={1991},
  volume={65 6},
  pages={
          3015-21
        }
}
A structural protein of hepatitis C virus (HCV) was expressed in monkey COS cells under the control of an exogenous promoter, and a protein of 22 kDa was identified by immunoblot analysis. This protein (p22), which was produced by processing in COS cells, reacted specifically to sera of chronic hepatitis C patients, and its coding region was mapped at the most amino-terminal part of the HCV polyprotein. These results suggested that the p22 protein is the nucleocapsid (core) protein of HCV… CONTINUE READING

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