Expression of pro-inflammatory and anti-inflammatory cytokines in brain of atherosclerotic rats and effects of Ginkgo biloba extract

@article{Jiao2005ExpressionOP,
  title={Expression of pro-inflammatory and anti-inflammatory cytokines in brain of atherosclerotic rats and effects of Ginkgo biloba extract},
  author={Yachong Jiao and Yao-cheng Rui and Tie-jun Li and Peng Yang and Yan Qiu},
  journal={Acta Pharmacologica Sinica},
  year={2005},
  volume={26},
  pages={835-839}
}
AbstractAim:To study the protein and mRNA expressions of pro-inflammatory and antiinflammatory cytokines in the brain of rats with atherosclerosis (AS) and the effects of Ginkgo biloba extract (GbE) on expressions of cytokines.Methods:The experimental model of AS in rats were established by intraperitioneal injection of vitamin D3 with high fat/cholesterol diet. GbE 100 mg/kg was administered to rats by ig. After 8 weeks, the expressions of IL-1β, TNF-α, IL-10, and IL-10R in the brain tissues… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Protective role of interleukin-10 in atherosclerosis.
TLDR
It is shown that IL-10-deficient C57BL/6J mice fed an atherogenic diet and raised under specific pathogen-free conditions exhibit a significant 3-fold increase in lipid accumulation compared with wild-type mice, which underscores the critical roles ofIL-10 in both atherosclerotic lesion formation and stability. Expand
Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death.
TLDR
IL-10, a potent anti-inflammatory cytokine, is expressed in a substantial number of advanced human atherosclerotic plaques and might contribute to the modulation of the local inflammatory response and protect from excessive cell death in the plaque. Expand
Inhibitory effect of extracts of Ginkgo biloba leaves on VEGF-induced hyperpermeability of bovine coronary endothelial cells in vitro.
TLDR
The inhibition of VEGF-induced permeability by EGb suggests that extracts of Ginkgo biloba leaves may have important clinical applications in the treatment of cardiovascular diseases. Expand
Colonic production and expression of IL-4, IL-6, and IL-10 in neonatal suckling rats after LPS challenge.
  • J. K. Adams, B. Tepperman
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2001
TLDR
It is shown that the suckling rat displays a different production and expression of colonic IL-4, IL-6, and IL-10 compared with weaned littermates after LPS challenge in rats, and neutrophils may be implicated in colonic cytokine expression after L PS challenge in Rats. Expand
Clinical significance of serum cytokines IL-1beta, sIL-2R, IL-6, TNF-alpha, and IFN-v in acute coronary syndrome.
TLDR
Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability. Expand
Effect of one week treatment with Ginkgo biloba extract (EGb761) on ischemia-induced infarct volume in gerbils.
TLDR
Results showed that the EGb761 group had significant reduction of infarct volume 4 and 6 mm from the frontal pole by 40% and 30%, respectively when compared to the control group (p < 0.05). Expand
Effects of Ginkgo Biloba Extract on Number and Activity of Endothelial Progenitor Cells from Peripheral Blood
TLDR
A novel functional effect of Ginkgo biloba extract is defined: the augmentation of endothelial progenitor cells with enhanced functional activity. Expand
Ginkgo biloba Extract (EGb761) and FK506 Preserve Energy Metabolites in the Striatum during Focal Cerebral Ischemia and Reperfusion in Gerbils Monitored by Microdialysis
TLDR
It is suggested that preservation of cellular energy metabolism during cerebral ischemia and after restoration with reperfusion may contribute to the neuroprotective effects of EGb761 and FK506. Expand
IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells.
TLDR
Concomitant induction ofIL-10R but not CRF2-4 to that of IL-10 by activated HSC in vitro and in vivo and associated acquisition of the responsiveness to IL- 10, entailing complex effects on HSC are shown. Expand
Serum Levels of the Antiinflammatory Cytokine Interleukin-10 Are Decreased in Patients With Unstable Angina
TLDR
Patients with unstable angina had significantly lower serum IL-10 concentrations than did patients with chronic stable angina, in keeping with previous data from animal model studies that suggest that IL- 10 has a protective role in atherosclerosis. Expand
...
1
2
...