Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome.

@article{Godoy2011ExpressionOP,
  title={Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome.},
  author={Heidi E. Godoy and Paulette Mhawech-Fauceglia and Amy F Beck and Austin Miller and Shashikant Lele and Kunle O Odunsi},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2011},
  volume={30 2},
  pages={139-44}
}
PARP, poly (adenosine diphosphate-ribose) polymerase, is a damage-sensing protein, which is essential for the repair of DNA single-strand breaks. PARP and p53 function synergistically in repairing DNA damage and suppressing chromosomal rearrangements. The aim of this study was to determine the expression of PARP and p53 in epithelial ovarian cancer (EOC) and to correlate their expression with clinicopathologic characteristics. PARP and p53 were evaluated using immunohistochemistry applied on a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…