Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells.

@article{Takeda2000ExpressionOP,
  title={Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells.},
  author={Torahiko Takeda and William Y. Go and Robert A. Orlando and Marilyn Gist Farquhar},
  journal={Molecular biology of the cell},
  year={2000},
  volume={11 9},
  pages={
          3219-32
        }
}
Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. However, until now there has been no direct evidence for podocalyxin's function. Podocalyxin is a type 1 transmembrane sialoprotein with an N-terminal mucin-like domain. To assess its function, we cloned rat podocalyxin and examined the… CONTINUE READING
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