Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation.

@article{Sokolov2010ExpressionOP,
  title={Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation.},
  author={Mykyta V. Sokolov and Irina V. Panyutin and Mykola I. Onyshchenko and Igor G. Panyutin and Ronald D. Neumann},
  journal={Gene},
  year={2010},
  volume={455 1-2},
  pages={
          8-15
        }
}
Human embryonic stem cells (hESC) are capable to give rise to all cell types in the human body during the normal course of development. Therefore, these cells hold a great promise in regenerative cell replacement based therapeutical approaches. However, some controversy exists in literature concerning the ultimate fate of hESC after exposure to genotoxic agents, in particular, regarding the effect of DNA damaging insults on pluripotency of hESC. To comprehensively address this issue, we… CONTINUE READING

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