Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats.

@article{Grappone1999ExpressionOP,
  title={Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats.},
  author={Cecilia Grappone and Massimo Pinzani and Maurizio Parola and Giulia Pellegrini and Alessandra Caligiuri and Raffaella M S Defranco and Fabio Marra and Hermann Herbst and Gianfranco D. Alpini and Stefano Milani},
  journal={Journal of hepatology},
  year={1999},
  volume={31 1},
  pages={100-9}
}
BACKGROUND/AIMS Chronic cholestasis stimulates a fibroductular reaction which may progress to secondary biliary fibrosis and cirrhosis. Since platelet-derived growth factor has been indicated as a major fibrogenic factor in chronic liver disease, we analyzed its expression and that of its receptor beta subunit in a rat model of chronic cholestasis. METHODS Liver tissue samples collected at 7, 10, 21, and 28 days after induction of cholestasis obtained by bile duct ligation, were analyzed by… CONTINUE READING