Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma.

@article{Sulzbacher2003ExpressionOP,
  title={Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma.},
  author={Irene Sulzbacher and Peter Birner and Margit Tr{\"a}xler and Michael J Marberger and Andrea Haitel},
  journal={American journal of clinical pathology},
  year={2003},
  volume={120 1},
  pages={107-12}
}
Platelet-derived growth factors (PDGFs) exert their biologic function by binding to 3 different tyrosine kinase receptor isoforms. Especially the PDGF-alpha alpha receptor binds PDGF proteins with high specificity, which results in growth stimulation. The expression of the receptor and its ligand was studied in human renal cell carcinomas (RCCs) by immunohistochemical analysis, and the expression of PDGF-alpha alpha receptor and PDGF-AA was correlated with clinicopathologic parameters of… CONTINUE READING

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