Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons.

@article{Cimini2005ExpressionOP,
  title={Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons.},
  author={Annamaria Cimini and Elisabetta Benedetti and Loredana Cristiano and Pierluigi Sebastiani and Maria Angela D'amico and Barbara D'Angelo and Silvia di Loreto},
  journal={Neuroscience},
  year={2005},
  volume={130 2},
  pages={325-37}
}
Neuronal differentiation is a complex process involving the sequential expression of several factors. The important role of lipid molecules in brain development is well known. Many fatty acid cell signaling activities are mediated by peroxisome proliferator-activated receptors (PPARs). PPARs are ligand-activated transcription factors belonging to the steroid, thyroid and retinoid nuclear receptor superfamily. They are activated by fatty acids and their derivatives. Different isotypes of PPARs… CONTINUE READING

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