Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation

@article{Demasi2013ExpressionOP,
  title={Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation},
  author={Ana Paula Dias Demasi and Elizabeth Ferreira Martinez and Marcelo Henrique Napimoga and Leandro Lu{\'i}s Lopes Freitas and Jos{\'e} Vassallo and Adriana Silva Santos Duarte and Andresa Borges Soares and Ney Soares de Ara{\'u}jo and Vera Cavalcanti de Ara{\'u}jo},
  journal={Virchows Archiv},
  year={2013},
  volume={463},
  pages={47-55}
}
B cell malignancies are classified according to the postulated differentiation stage of the originating cell. During differentiation, structural and molecular changes occur to support massive processing of immunoglobulin in the endoplasmic reticulum (ER) of plasma cells at the final stage. When overloaded, the ER generates unfolded proteins and hydrogen peroxide (H2O2), which may cause cell death. Peroxiredoxins (Prxs) I and IV belong to a family of proteins able to catalyze peroxide… CONTINUE READING
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