Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves

@article{Burnett2000ExpressionOP,
  title={Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves},
  author={MD AL Burnett},
  journal={International Journal of Impotence Research},
  year={2000},
  volume={13},
  pages={362-362}
}
Penile erection is mediated by nitric oxide (NO) synthesized by the neuronal nitric oxide synthase (nNOS). In the rat penis, the main nNOS mRNA variant, PnNOS, differs from cerebellar nNOS (CnNOS) by a 102 base pair insert encoding a 34-amino acid sequence. In the mouse, two nNOS mRNAs have been identified: nNOSalpha, encoding a 155-kDa protein, and an exon 2-deletion variant, nNOSbeta, encoding a 135-kDa protein that lacks a domain where a protein inhibitor of nNOS (PIN) binds. We wished to… CONTINUE READING