Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma.

@article{Cai2012ExpressionOP,
  title={Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma.},
  author={Hong-xing Cai and Liu Yang and Xiang Song and Zhouru Liu and Yan-Bo Chen and Guokai Dong},
  journal={Molecular medicine reports},
  year={2012},
  volume={5 2},
  pages={
          469-72
        }
}
The objective of the present study was to investigate the expression of paxillin and focal adhesion kinase (FAK) mRNA in esophageal carcinoma tissues, and their relationship with clinicopathological parameters, as well as to analyze the correlation of paxillin and FAK mRNA levels in esophageal carcinoma. By using reverse transcription polymerase chain reaction (RT-PCR), the mRNA expression levels of paxillin and FAK were detected in… 
View on PubMed
spandidos-publications.com
16 Citations
Highly Influential Citations
2
Background Citations
5
Results Citations
1

16 Citations

Citation Type

Citation Type

Abstract. Paxillin encodes a focal adhesion-associated protein and is involved in the progression and aggressive phenotypes of malignancies through its interactions with the actin cytoskeleton and key signal transduction oncogenes. The present study aimed to investigate the clinicopathological and p
  • 2013
Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas
TLDR
Aberrant paxillin expression may be involved in the growth, invasion, metastasis and differentiation of gastric carcinoma and may be employed as an indicator of pathobiological behaviors and prognosis of Gastric carcinomas.
Expression of Paxillin in Benign and Malignant Salivary Gland Tumors
TLDR
High expression of pxillin was observed in tumoral tissues compared with the controls that establish an important role of paxillin in SGTs but its prognostic role was unclear and need further evaluation.
Fascin-1, Ezrin and Paxillin Contribute to the Malignant Progression and Are Predictors of Clinical Prognosis in Laryngeal Squamous Cell Carcinoma
TLDR
Finn-1, ezrin and paxillin may be prognostic of poor outcome with LSCC after surgery and may lead to establishing new molecular therapeutic targets and/or prognostic biomarkers in LSCC.
Evaluation of Cytoskeleton-Associated Proteins; Ezrin, Podocalyxin and Paxillinin Urothelial Carcinoma of the Urinary Bladder
TLDR
The results suggest that ezrin, podocalyxin and paxillin could be valuable prognostic molecules in evaluation of UCB and this might lead to establishment of new molecular therapeutic strategy and prognostic biomarkers in UCB.
A four actin-binding protein signature model for poor prognosis of patients with esophageal squamous cell carcinoma.
TLDR
The results demonstrate that the collective protein expression pattern of four actin-binding proteins could be a biomarker to estimate the prognosis of ESCC patients.
Paxillin suppresses the proliferation of HPS rat serum treated PASMCs by up-regulating the expression of cytoskeletal proteins.
TLDR
Down-regulation of paxillin by siRNA results in the inhibition of the dysregulation of cytoskeletal proteins and proliferation of PASMCs, suggesting a potential therapeutic effect on PVR associated with HPS.
Biology of Human Tumors Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT 5 A
TLDR
The findings suggest that NRP1 is a critical downstream effector of CRT in promoting cell migration and invasion, which might contribute to the metastasis of ESCC.
Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
TLDR
The findings suggest that NRP1 is a critical downstream effector of CRT in promoting cell migration and invasion, which might contribute to the metastasis of ESCC.
Focal adhesion kinase: Insight into its roles and therapeutic potential in oesophageal cancer.
...
1
2
...

References

SHOWING 1-10 OF 13 REFERENCES
Immunohistochemical evaluation of p53, FHIT, and IGF2 gene expression in esophageal cancer.
  • S. Chava, V. Mohan, +7 authors Q. Hasan
  • Medicine
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • 2012
The aim of the study was to evaluate the expression of tumor suppressor genes p53, fragile histidine triad gene (FHIT), and an oncogene insulin-like growth factor 2 (IGF2) as prognostic markers in…
Increased Expression of Paxillin is Found in Human Oesophageal Squamous Cell Carcinoma: A Tissue Microarray Study
  • B. Li, W. Lei, +14 authors J. He
  • Medicine
    The Journal of international medical research
  • 2008
TLDR
Paxillin was over-expressed in tumours in 27/100 cases, compared with 6/ 100 cases for adjacent non-tumoural cells, hence paxillin is not an effective prognostic marker in these patients.
Clinical significance of FAK expression in human neoplasia.
TLDR
The purpose of this article is a comprehensive review of the existing data on FAK expression and signaling and their clinical significance in human malignancy.
Absence of paxillin gene mutation in lung cancer and other common solid cancers.
TLDR
It is revealed that PxN mutation was absent in lung cancers and other common solid cancers, suggesting that PXN mutation may not play a principal role in solid cancer development.
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways.
TLDR
Results provide compelling evidence that the potential pan-ST inhibitor, Lith-O-Asp, suppressed cancer cell metastasis likely by inhibiting FAK/paxillin signaling and expressing antiangiogenesis factors.
Investigating the Pathogenic Role of PADI4 in Oesophageal Cancer
TLDR
The results suggest that P ADI4 expression is related to the tumorigenic process of EC and the DCA-induced apoptosis and the PADI4 gene may be a valid EC susceptibility gene.
Profilin-1 is a negative regulator of mammary carcinoma aggressiveness
TLDR
It is shown that loss of Pfn1 expression leads to enhanced motility and matrigel invasiveness of MDA-MB-231 breast cancer cells, and furthermore, animal experiments reveal that overexpression of P fn1 suppresses orthotopic tumorigenicity and micro-metastasis of Mda- MB-231 cells in nude mice, implying that perturbing Pfn 1 could be a good molecular strategy to limit the aggressiveness of Breast cancer cells.
Correlation of overall survival with gene expression profiles in a prospective study of resectable esophageal cancer.
TLDR
This initial study has highlighted groups of tumors with distinct gene expression profiles based on survival and warrants further validation in a larger cohort.
Involvement of phosphorylation of tyr‐31 and tyr‐118 of paxillin in MM1 cancer cell migration
TLDR
It is demonstrated that LPA collaborates with FN for persistent tyrosine phosphorylation of paxillin at both Y31 and Y118, regulated by the Na+/H+ antiporter downstream of ROCK and that this phosphorylated pxillin is essential for MM1 cancer cell migration.
Brk Activates Rac1 and Promotes Cell Migration and Invasion by Phosphorylating Paxillin
TLDR
It is shown that EGF stimulation activates the catalytic activity of Brk, which in turn phosphorylates paxillin at Y31 and Y118, which promotes the activation of small GTPase Rac1 via the function of CrkII.
...
1
2
...