Expression of pax6 and sox2 in adult olfactory epithelium.

  title={Expression of pax6 and sox2 in adult olfactory epithelium.},
  author={Zhen Guo and Adam I. Packard and Richard C. Krolewski and Margaret T Harris and Glen L Manglapus and James E Schwob},
  journal={The Journal of comparative neurology},
  volume={518 21},
The olfactory epithelium maintains stem and progenitor cells that support the neuroepithelium's life-long capacity to reconstitute after injury. However, the identity of the stem cells--and their regulation--remain poorly defined. The transcription factors Pax6 and Sox2 are characteristic of stem cells in many tissues, including the brain. Therefore, we assessed the expression of Pax6 and Sox2 in normal olfactory epithelium and during epithelial regeneration after methyl bromide lesion or… CONTINUE READING
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