Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.

@article{Lee1995ExpressionOP,
  title={Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.},
  author={Kyongbum Lee and Jake Deeds and Gino V. Segre},
  journal={Endocrinology},
  year={1995},
  volume={136 2},
  pages={453-63}
}
PTH-related peptide (PTHrP) is a causative agent of hypercalcemia associated with malignancy. PTHrP binds to and activates the same receptor as does PTH. Because PTHrP has been suggested to regulate the growth and differentiation of cells as a paracrine/autocrine factor, we examined the expression of both PTHrP and its receptor genes during fetal development of rats (15-20 days gestation) by in situ hybridization with riboprobes. Both PTHrP and its receptor messenger RNAs (mRNAs) were expressed… CONTINUE READING

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