Expression of p75(NTR), trkB and trkC in nonmanipulated and axotomized motoneurons of aged rats.

@article{Johnson1999ExpressionOP,
  title={Expression of p75(NTR), trkB and trkC in nonmanipulated and axotomized motoneurons of aged rats.},
  author={Helena Johnson and Tomas G M H{\"o}kfelt and Brun Ulfhake},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={69 1},
  pages={21-34}
}
Several lines of evidence indicate that adult neurons remain dependent on neurotrophins and that changes in tissue expression of neurotrophins and/or their receptors may play a role in senile neurodegeneration. We have studied the expression of p75NTR, trkB and trkC, respectively, in lumbar motoneurons of young adult (2-3 months) and aged (30 months) rats subjected to sciatic transection using in situ hybridization and immunohistochemistry. Nonmanipulated age-matched animals were processed in… CONTINUE READING