Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma.

@article{Tannapfel1999ExpressionOP,
  title={Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma.},
  author={Andrea Tannapfel and Morten Wasner and K T Krause and Felix Geissler and Alexander Katalinic and Johann Hauss and Joachim Moessner and Kurt Engeland and Ch Wittekind},
  journal={Journal of the National Cancer Institute},
  year={1999},
  volume={91 13},
  pages={1154-8}
}
BACKGROUND The protein p73, the first identified homologue of the tumor suppressor gene p53 (also known as TP53), has been shown to induce apoptosis (programmed cell death), but its function in tumor development has not been established. This study was undertaken to investigate the expression of p73 in liver tissue of patients with hepatocellular carcinoma (HCC) and to determine whether this expression has any impact on prognosis. METHODS In situ hybridization and immunohistochemistry for the… CONTINUE READING