Expression of p57(KIP2) in hepatocellular carcinoma: relationship between tumor differentiation and patient survival.

@article{Nakai2002ExpressionOP,
  title={Expression of p57(KIP2) in hepatocellular carcinoma: relationship between tumor differentiation and patient survival.},
  author={Seiji Nakai and Tsutomu Masaki and Yasushi Shiratori and Tomohiro Ohgi and Asahiro Morishita and Kazutaka Kurokohchi and Seishiro Watanabe and Shigeki Kuriyama},
  journal={International journal of oncology},
  year={2002},
  volume={20 4},
  pages={769-75}
}
Cyclins, cyclin-dependent kinases (CDK), and CDK inhibitors (CKI) are frequently altered in neoplasm. p57(KIP2) is a member of the KIP (kinase inhibitory protein) family of CKI and is a potential tumor suppressor gene. p27(KIP1) is the most extensively studied KIP family member with respect to the clinical significance in human neoplasms. However, the clinical significance of p57(KIP2) expression in patients with human cancers, including hepatocellular carcinoma (HCC), remains unknown. This… CONTINUE READING