Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications.

  title={Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications.},
  author={Anthony P. Albino and Jon Reed and J K Bogdany and Judyth Sassoon and Rosemary B Desloge and Simon C Parisier},
  journal={The American journal of otology},
  volume={19 1},
BACKGROUND Cholesteatoma is a destructive lesion of the middle ear or mastoid process or both. The molecular and cellular defects that result in the clinical hallmarks of acquired and congenital cholesteatomas, namely invasion, migration, uncoordinated proliferation, altered differentiation, aggressiveness, and recidivism, are unknown. Determining the existence of defects in the normal biology, biochemistry, and genetic complement of the major cellular constituents comprising a cholesteatoma (i… CONTINUE READING


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