Expression of p53 in premalignant and malignant squamous epithelium.

  title={Expression of p53 in premalignant and malignant squamous epithelium.},
  author={Barry Gusterson and Ramaswamy Anbazhagan and Wesley Warren and Carol Midgely and D. P. Lane and M O'hare and Alasdair C Stamps and R Carter and Hiran Jayatilake},
  volume={6 10},
Using three antibodies (JG8, CM-1 and 1081) directed to the p53 protein, strong positivity was found in 16/47 (34.0%) of mucosal squamous cell carcinomas of the head and neck and in two squamous carcinoma cell lines (LICR-LON- HN5 and HN6Rr). The presence of the mutant p53 was confirmed in the cell lines as substitutions in exon 7 (codon 238, TGT greater than AGT) and exon 5 (codon 152, CCG greater than CTG) respectively. Positive staining was seen only in the undifferentiated cells and… CONTINUE READING
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