Expression of p53 and p21CIP1/WAF1 proteins in oral epithelial dysplasias and squamous cell carcinomas.

@article{Kudo1999ExpressionOP,
  title={Expression of p53 and p21CIP1/WAF1 proteins in oral epithelial dysplasias and squamous cell carcinomas.},
  author={Yasusei Kudo and Takashi Takata and Ikuko Ogawa and Sunao Sato and Hiromasa Nikai},
  journal={Oncology reports},
  year={1999},
  volume={6 3},
  pages={539-45}
}
The expression of tumor suppressor gene, p53 and cyclin-dependent kinase inhibitor, p21 in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) was examined immunohistochemically and its relationship with clinicopathological findings was analyzed. Among 24 epithelial dysplasias, 4 cases (17%) expressed p53 protein and 23 cases (96%) expressed p21 protein. On the other hand, expression of p53 was observed in 64% of OSCCs, and expression of p21 was observed in 77% of OSCCs. In the… CONTINUE READING

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