Expression of p53 and p16 in actinic keratosis, bowenoid actinic keratosis and Bowen's disease

  title={Expression of p53 and p16 in actinic keratosis, bowenoid actinic keratosis and Bowen's disease},
  author={Lorea Bagazgoitia and Jes{\'u}s Cuevas and {\'A}ngeles Juarranz},
  journal={Journal of the European Academy of Dermatology and Venereology},
Introduction  Bowen's disease (BD) and bowenoid actinic keratosis (bAK) have traditionally been differentiated according to the presence or absence of dysplasia in the follicular epithelium. p16 has been suggested to be a useful tool to make the differential diagnosis between BD and AK and as a marker of bad prognosis. 
Atypical intraepidermal keratinocytic lesions falling short of carcinoma in situ (Bowen disease) on routine staining: the utility of p16 immunostaining
Keywords: actinic keratosis; Bowen disease; p16; seborrheic keratosis; squamous cell carcinoma in situ
Clonal highlights: Clonal seborrheic keratoses often demonstrates p16 expression
This work investigates p16 immunohistochemistry in CSK, SK, and BD to find out if there is a relationship between CSK and p16 expression and Bowen disease.
Use of proliferation rate, p53 staining and perforating elastic fibers in distinguishing keratoacanthoma from hypertrophic lichen planus: a pilot study
This work has shown that differentiation between keratoacanthoma and hypertrophic lichen planus histopathologically can be difficult, and the challenge is compounded by the tendency of KA to arise in association with hypertrophic LP.
Claudin‐1 expression decreases with increasing pathological grade in actinic keratosis and may be a marker of high‐risk actinic keratosis
There is still no reliable method to predict high‐risk AK, but there is a growing awareness of the need to understand more fully the risks and benefits of sun‐induced keratosis.
Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant
A case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma is presented.
p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern
For selecting therapy, it is important to distinguish different types of keratinocytic neoplasia, especially in organ transplant recipients (OTR) who develop numerous lesions.
Clonal Seborrheic Keratosis Versus Pagetoid Bowen Disease: Histopathology and Role of Adjunctive Markers
There is no single reliable criterion to distinguish CSK from PBD, but a panel of markers comprising CK10, Ki-67, and p16 seems to be useful in the context of relevant histology.
Different Immunohistochemical Localization of Fatty Acid Binding Protein 5 in Actinic Keratosis Compared with That in Bowen's Disease: A Retrospective Study.
The unique immunohistochemical localization of the FABP5 can be a helpful diagnostic marker, and altered fatty acid metabolism may be the key in understanding the different pathophysiology of AK and BD.
Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis
Investigation of the presence of Merkel cell polyomavirus (MCPyV) in relation to p16 expression in Seborrheic keratosis found it to be a coincidental infection, and P16 IHC does not appear as useful adjunctive surrogate marker for the existence of MCPYV in SK.
Immunohistochemical staining for p16 is a useful adjunctive test in the diagnosis of Bowen's disease
Bowen's disease shows a distinctive, repeatable pattern of staining with p16, characterised by moderate to strong staining of all abnormal cells with sparing of a layer of basal cells, which is not seen in actinic keratosis or in seborrheic keratoses.


p16INK4a expression in actinic keratosis and Bowen's disease
Background  Progression of cutaneous squamous neoplasms from actinic keratosis (AK) to Bowen's disease (BD; squamous cell carcinoma in situ) has important implications for clinical management and
Correlation of p16 and pRb expression with HPV detection in Bowen’s disease
It is shown that p16 over‐expression is a surrogate marker of HPV E7‐mediated catabolism of pRb in premalignant and malignant lesions of the cervical mucosa and the correlation of p16 and pRB expression with HPV detection in Bowen’s disease has not been well characterized.
An Assessment of the Malignant Potential of Actinic Keratoses and Bowen's Disease: p53 and PCNA Expression Pattern Correlate with the Number of Desmosomes
It is hypothesized that atrophic and acantholytic types of AK might have the lowest, and the bowenoid type of AK and BD may have the highest, malignant potential.
Low prevalence of p53, p16INK4a and Ha‐ras tumour‐specific mutations in low‐graded actinic keratosis
Different mutation rates of p53, p16INK4a and Ha‐ras in cutaneous squamous cell carcinoma and the earlier stage actinic keratosis have been reported.
Immunophenotypic analysis of the p53 gene in non‐melanoma skin cancer and correlation with apoptosis and cell proliferation
The p53 tumour suppressor gene, which plays a pivotal role in cell division and apoptosis, is frequently found mutated in sunlight‐induced skin tumours.
Immunohistochemical Staining of Palisading Basal Cells in Bowen's Disease and Basal Involvement in Actinic Keratosis: Contrasting Staining Patterns Suggest Different Cells of Origin
Lack of expression of proliferative antigens in palisading basal cells in BD provides evidence that PBCs are not the cell of origin for BD, whereas in AK, expression of MIB-1 and p53 in basal cells argues that these cells play a role in histogenesis of AK.
P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas.
It is demonstrated that the expression of P16 and Ki67 is associated with skin carcinomas, and within cutaneous carcinoma specimens, P16 overexpression was significantly associated with the location on sun-exposed areas, suggesting a possible induction of P 16 overeexpression by UV radiation.
Immunohistochemical Comparison of P16 Expression in Actinic Keratoses and Squamous Cell Carcinomas of the Skin
There are approximately 200,000 new cases of cutaneous squamous cell carcinoma diagnosed each year in the United States, with between 1300 and 2300 deaths per year from metastatic disease. The tumor
Bowen's Disease: A Four‐Year Retrospective Review of Epidemiology and Treatment at a University Center
The most common locations for BD were in areas with high sun exposure and multiple treatment options are available and recurrence is uncommon, but Margin control surgery should be considered for tumors in high-risk areas.