Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.

@article{Kazakov2010ExpressionOP,
  title={Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.},
  author={Dmitry V Kazakov and Patrick Grossmann and Dominic V. Spagnolo and Tom{\'a}{\vs} Vaně{\vc}ek and Marina Vazmitel and Denisa Kacerovsk{\'a} and Bernhard Zelger and Eduardo J Calonje and M Igielski Michal},
  journal={The American Journal of dermatopathology},
  year={2010},
  volume={32 3},
  pages={
          215-21
        }
}
We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. At least weak and focal p53 positivity was present in 13 of the 15 lesions. Successful PCR and sequencing were possible in 12 of the 15 cases. In one case only there were 2 p53 mutations, one being a c.673-1G>A splice-site mutation in the 3'-end… CONTINUE READING
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