Expression of p27kip1 and Skp2 in the adult spinal cord following sciatic nerve injury

@article{Shi2007ExpressionOP,
  title={Expression of p27kip1 and Skp2 in the adult spinal cord following sciatic nerve injury},
  author={S. Shi and Aiguo Shen and Chun Cheng and M. Chen and Jing Qin and Shang-feng Gao and Jing Zhao},
  journal={Journal of Molecular Neuroscience},
  year={2007},
  volume={32},
  pages={64-71}
}
Skp2 (S-phase-associated kinase protein-2) is involved in ubiquitination and proteasome-mediated degradation of p27kip1, which plays important roles in cell cycle regulation and neurogenesis in the developing central nervous system (CNS). But their distribution and function in the nervous system lesion and regeneration remains unclear. In this study, we examined expression and relationship of p27kip1 and Skp2 in adult rat spinal cord following sciatic nerve injury. It was illustrated that they… CONTINUE READING