Expression of p21Waf1/Cip1 predicts response and survival of esophageal cancer patients treated by chemoradiotherapy.

@article{Nakamura2004ExpressionOP,
  title={Expression of p21Waf1/Cip1 predicts response and survival of esophageal cancer patients treated by chemoradiotherapy.},
  author={Taichi Nakamura and Kunioki Hayashi and Masaho Ota and Hiroko Ide and Ken Takasaki and Miyuki Mitsuhashi},
  journal={Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus},
  year={2004},
  volume={17 4},
  pages={315-21}
}
Chemoradiotherapy is a multimodal therapy routinely used as a primary treatment for advanced esophageal cancer. However, it is beneficial only to patients who respond. To identify pretreatment markers predicting response and survival, we examined the expression of cell cycle regulatory molecules, p53, p21(Waf1/Cip1) cyclin D1, and CDC25B, in biopsy specimens from 76 patients with stage III and stage IV squamous cell carcinoma. Overexpression of p53, p21, cyclin D1 and CDC25B was observed in 58… CONTINUE READING