Expression of p21/WAF-1, status of apoptosis and p53 mutation in esophageal squamous cell carcinoma with HPV infection.

@article{Hasegawa2002ExpressionOP,
  title={Expression of p21/WAF-1, status of apoptosis and p53 mutation in esophageal squamous cell carcinoma with HPV infection.},
  author={Makoto Hasegawa and Izuru Ohoka and Kazuto Yamazaki and Kyota Hanami and Isamu Sugano and Toshitaka Nagao and Akira Asoh and Nobuaki Wada and Koichi Nagao and Yasuo Ishida},
  journal={Pathology international},
  year={2002},
  volume={52 7},
  pages={442-50}
}
Human papilloma virus (HPV) is regarded as a causative carcinogenic agent in anogenital squamous cell carcinoma (SCC), but there is controversy about its etiologic role in esophageal SCC (ESCC). In this study, we attempted to clarify whether HPV infection plays a crucial role in the development of ESCC by analysis of multiple factors. These included: detection of HPV DNA; evaluation of immunohistochemical assays for HPV-related cell cycle regulators and apoptosis by the terminal… CONTINUE READING

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