Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus.

@article{Klumann2003ExpressionOP,
  title={Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus.},
  author={Jens Klu\ssmann and Elif Sibel G{\"u}ltekin and Soenke Jan Weissenborn and Ulrike Wieland and Volker Dries and Hans Peter Dienes and Hans Edmund Eckel and Herbert J. Pfister and Pawel G. Fuchs},
  journal={The American journal of pathology},
  year={2003},
  volume={162 3},
  pages={747-53}
}
Recent analyses of head and neck squamous cell carcinomas revealed frequent infections by oncogenic human papillomavirus (HPV) type 16 in tonsillar carcinomas. Concerning involvement of risk factors, clinical course of the disease, and prognosis there are strong indications arguing that the HPV-positive tonsillar carcinomas may represent a separate tumor entity. Looking for a surrogate marker, which in further epidemiological studies could replace the laborious and expensive HPV detection and… CONTINUE READING
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