Expression of osteoprotegerin and RANK ligand in breast cancer bone metastasis.

@article{Park2003ExpressionOO,
  title={Expression of osteoprotegerin and RANK ligand in breast cancer bone metastasis.},
  author={H R Park and Soo-Kee Min and Hyun-Deuk Cho and Duck-Hwan Kim and Hyung Sik Shin and Young Euy Park},
  journal={Journal of Korean Medical Science},
  year={2003},
  volume={18},
  pages={541 - 546}
}
Bone destruction is primarily mediated by osteoclastic bone resorption, and cancer cells stimulate the formation and activation of osteoclasts next to metastatic foci. Accumulating evidences indicate that receptor activator of NF-kB ligand (RANKL) is the ultimate extracellular mediator that stimulates osteoclast differentiation into mature osteoclasts. In… CONTINUE READING