Expression of osteoclast differentiation signals by stromal elements of giant cell tumors.

@article{Atkins2000ExpressionOO,
  title={Expression of osteoclast differentiation signals by stromal elements of giant cell tumors.},
  author={Gerald James Atkins and David Haynes and Stephen E Graves and Andreas Evdokiou and Shelley J Hay and Stelios Bouralexis and David M. Findlay},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2000},
  volume={15 4},
  pages={640-9}
}
The mechanisms by which primary tumors of the bone cause bone destruction have not been elucidated. Unlike most other lytic bone tumors, osteoclastomas, otherwise known as giant cell tumors (GCT), contain osteoclast-like cells within the tumor stroma. A new member of the TNF-ligand superfamily member, osteoclast differentiation factor (ODF/OPGL/RANKL/TRANCE), was recently identified. ODF was shown to directly stimulate osteoclastogenesis, in the presence of M-CSF. In this study, the expression… CONTINUE READING
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