Expression of oncogenes in thyroid tumours: coexpression of c-erbB2/neu and c-erbB.

  title={Expression of oncogenes in thyroid tumours: coexpression of c-erbB2/neu and c-erbB.},
  author={Rein Aasland and Johan Richard Lillehaug and Rene Male and O. J{\~A}¸sendal and Jan Erik Varhaug and Kjell Kleppe},
  journal={British Journal of Cancer},
  pages={358 - 363}
The receptor-type oncogenes c-erbB2/neu and c-erbB have been found amplified and/or overexpressed in a number of tumours of epithelial origin. We have studied the expression of oncogenes in biopsies from human thyroid tumours. The c-erbB2/neu and c-erbB oncogenes showed two- to three-fold higher levels of RNA in papillary carcinomas and lymph node metastases as well as in one adenoma when compared to non-tumour tissue. The nuclear oncogenes c-myc and c-fos were found to be expressed at varying… CONTINUE READING


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