Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.

@article{Rousseau2006ExpressionOO,
  title={Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.},
  author={Audrey Rousseau and Catherine L. Nutt and Rebecca A. Betensky and Anthony John Iafrate and Moonjoo Han and Keith L Ligon and David H Rowitch and David N Louis},
  journal={Journal of neuropathology and experimental neurology},
  year={2006},
  volume={65 12},
  pages={1149-56}
}
The phenotypic heterogeneity of astrocytic and oligodendroglial tumor cells complicates establishing accurate diagnostic criteria, and lineage-specific markers would facilitate diagnosis of glioma subtypes. Based on data from the literature and from expression microarrays, we selected molecules relevant to gliogenesis and glial lineage specificity and then used immunohistochemistry to assess expression of these molecules in 55 diffuse gliomas, including 8 biphasic oligoastrocytomas, 21… CONTINUE READING