Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα

@inproceedings{Collins2009ExpressionOO,
  title={Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα},
  author={Frances Collins and Sheila Macpherson and Pamela Brown and Vincent Bombail and Alistair Rw Williams and Richard A. Anderson and Henry N. Jabbour and Philippa T. K. Saunders},
  booktitle={BMC Cancer},
  year={2009}
}
Endometrial cancer is the most common gynaecological malignancy; risk factors include exposure to oestrogens and high body mass index. Expression of enzymes involved in biosynthesis of oestrogens and prostaglandins (PG) is often higher in endometrial cancers when compared with levels detected in normal endometrium. Oestrogens bind one of two receptors (ERα and ERβ) encoded by separate genes. The full-length receptors function as ligand-activated transcription factors; splice variant isoforms of… CONTINUE READING

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