Expression of novel secreted isoforms of human immunoglobulin E proteins.

  title={Expression of novel secreted isoforms of human immunoglobulin E proteins.},
  author={J. B. Lyczak and Kun Zhang and Andrew Saxon and Sherie L. Morrison},
  journal={The Journal of biological chemistry},
  volume={271 7},
Four human IgE isoforms produced by alternative splicing of the epsilon primary transcript were expressed as chimeric mouse/human anti 5-dimethylamino-1-naphthalenesulfonyl antibodies in the murine myeloma cell line Sp2/0. The four isoforms include the classic secreted form and three novel isoforms with altered carboxyl termini. All of these isoforms lack the transmembrane region encoded by the M1/M1' exon and are therefore predicted to be secreted proteins. When expressed in Sp2/0 cells, three… CONTINUE READING

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