Expression of novel DNA-binding protein with zinc finger structure in various tumor cells.

@article{Tagawa1990ExpressionON,
  title={Expression of novel DNA-binding protein with zinc finger structure in various tumor cells.},
  author={Masami Tagawa and Takashi Sakamoto and Kazuhiro Shigemoto and Hiroaki Matsubara and Yoshiaki Tamura and Takashi Ito and Ichiro Nakamura and Akira Okitsu and Kenichi Imai and Masaru Taniguchi},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 32},
  pages={20021-6}
}
We have isolated from B16 mouse melanoma cells a complementary DNA (Mel-18), whose deduced amino acid sequence possesses a characteristic zinc finger structure. Immunostaining with antibodies raised against partial Mel-18 peptide sequences demonstrated nuclear localization of the gene product. We have also demonstrated that this protein has DNA-binding capacity, and the zinc finger is responsible for the DNA binding. At the transcriptional level the Mel-18 mRNA was detected in all tumor cells… CONTINUE READING
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