Expression of normal and mutant huntingtin in the developing brain.

  title={Expression of normal and mutant huntingtin in the developing brain.},
  author={Pradeep G Bhide and Michelle C. Day and Ellen Sapp and Cornelius Schwarz and Archna Sheth and Jinhyun Kim and Anne B. Young and Jay Penney and Jeffrey C Golden and Neil Aronin and Marian Difiglia},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={16 17},
Huntington's disease (HD) is caused by a genetic mutation that results in a polyglutamine expansion in huntingtin. The time course of neuronal loss in the HD striatum and other affected brain regions before the onset of symptoms is unknown. To determine the potential influence of huntingtin on brain development, we examined its expression in the developing mouse and in human control and HD brain. By Western blot, huntingtin was detected throughout the adult mouse brain and at all stages of… CONTINUE READING
61 Citations
58 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 61 extracted citations


Publications referenced by this paper.
Showing 1-10 of 58 references

Sensitivity of developing brain to hypobaric/ischemic damage parallels sensitivity to NMDA

  • D Ikonomidou, JL Mosinger, K Salles, J Olney
  • J Neurosci
  • 1989
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…