Expression of nm23 in cell lines derived from patients with metastatic renal cell carcinoma.

@article{Walther1995ExpressionON,
  title={Expression of nm23 in cell lines derived from patients with metastatic renal cell carcinoma.},
  author={M. M. Walther and Patrick Anglard and James R. Gnarra and Rudy O. Pozzatti and David J Venzon and Abel De La Rosa and Nicholas J Macdonald and Patricia S. Steeg and W. Marston Linehan},
  journal={The Journal of urology},
  year={1995},
  volume={154 1},
  pages={278-82}
}
Reduced expression of nm23 has been associated with increased metastases and decreased survival in a variety of malignancies. In the present study, the expression of nm23 was examined by Northern and Western blot analyses in a series of cell lines derived from patients with metastatic renal cell carcinoma. Two of twelve (17%) informative cell lines derived from 9 patients had loss of heterozygosity at Nm23-H1. Twenty-two renal cancer cell lines derived from primary tumors, 5 cell lines derived… CONTINUE READING