Expression of nm23‐Hl and nm23‐H2 Proteins in Prostate Carcinoma

  title={Expression of nm23‐Hl and nm23‐H2 Proteins in Prostate Carcinoma},
  author={Noboru Konishi and Shingo Nakaoka and Toshihide Tsuzuki and Kyoichi Matsumoto and Yoshiteru Kitahori and Yoshio Hiasa and Takeshi Urano and Hiroshi Shiku},
  booktitle={Japanese journal of cancer research : Gann},
The nm23 gene products/nucleoside diphosphate (NDP) kinase expression in prostate carcinomas and benign hyperplasias was evaluated immunohistochemically. Monoclonal antibodies against nm23-H1 and nm23-H2 proteins were prepared using the corresponding proteins fused with glutathione S-transferase as immunogens. Of the 80 cases of nonmetastatic prostate carcinoma examined, 74% (59/80) and 60% (48/80) were immunoreactive for nm23-H1 or nm23-H2 protein, respectively. Negative staining for nm23-H1… CONTINUE READING

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