Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action.

@article{Kapur1997ExpressionON,
  title={Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action.},
  author={Sonia Kapur and St{\'e}phane B{\'e}dard and Barbara Marcotte and Claude H. C{\^o}t{\'e} and Andr{\'e} Marette},
  journal={Diabetes},
  year={1997},
  volume={46 11},
  pages={1691-700}
}
Previous studies have shown that nitric oxide synthase (NOS), the enzyme that catalyzes the formation of nitric oxide (NO), is expressed in skeletal muscle. The aim of the present study was to test the hypothesis that NO can modulate glucose metabolism in slow- and fast-twitch skeletal muscles. Calcium-dependent NOS was detected in skeletal muscle, and the enzyme activity was greater in fast-type extensor digitorum longus (EDL) muscles than in slow-type soleus muscles. Both the neuronal-type… CONTINUE READING

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