Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents.

@article{Condorelli1994ExpressionON,
  title={Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents.},
  author={Daniele Filippo Condorelli and Paola Dell'Albani and Giuseppa Mud{\`o} and T{\~o}nis Timmusk and Natale Belluardo},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 2},
  pages={509-16}
}
By northern blot analysis and ribonuclease protection assay, we observed the presence of a high level of trkB mRNA in primary brain cultures devoid of neuronal cells and highly enriched in glial fibrillary acidic protein-positive astroglial cells prepared from newborn rat cerebral hemispheres, cerebral cortex, hippocampus, and striatum. In primary astroglial cultures, the more abundant trkB transcripts code for the truncated receptor without tyrosine kinase activity; probes specific for the… CONTINUE READING

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