Expression of neurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnatal development.

@article{Kaisho1994ExpressionON,
  title={Expression of neurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnatal development.},
  author={Yoshihiko Kaisho and Masaomi Miyamoto and Osamu Shiho and Hitoshi Onoue and Yoshihisa Kitamura and Sakashi Nomura},
  journal={Brain research},
  year={1994},
  volume={647 1},
  pages={139-44}
}
We compared the expression patterns of neurotrophin genes in the brain of senescence-accelerated mouse (SAMP8) which shows age-related impairment of learning behavior, with SAMR1 control which shows normal aging. By Northern blot analysis, NT-3 mRNA levels in the cortex were higher in SAMP8 than in SAMR1 mice during development, whereas in the midbrain, hippocampus and forebrain, NT-3 expression levels in SAMP8 were lower than those in SAMR1. At early stages, although NGF mRNA levels in SAMP8… CONTINUE READING

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