Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation

@article{Obata2002ExpressionON,
  title={Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation},
  author={Kunihiko Obata and Hiroaki Tsujino and Hiroki Yamanaka and Dai Yi and Koichi Noguchi},
  journal={PAIN},
  year={2002},
  volume={99},
  pages={121-132}
}
A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in lumbar disc herniation. In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniation, we evaluated pain-related behavior and the change of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRG and dorsal root using a rat… CONTINUE READING
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